Search
Search

Hemoperfusion Cartridges

Hemoperfusion Cartridges Introduction

In clinical settings, blood purification techniques achieve molecular separation primarily by membrane-based and adsorptive processes. Solute removal in Hemodialysis and other blood purification techniques is mainly achieved by diffusion and convection. However, the limitations imposed by the characteristics of some solutes and the structure of dialysis membranes have spurred new interest in the use of further mechanisms of solute removal such as adsorption.

When the former techniques using diffusion and convection are inadequate to remove the target molecules from the patient’s blood, the use of sorbents and hemoperfusion (HP) may become a promising additional option for blood purification.

In HP, blood is circulated through a unit (cartridge) containing the solid sorbent material. Solute removal and blood purification are obtained by adsorption (binding) of molecules onto the sorbent particles.

Sorbents can be composed of natural or synthetic materials. In the past, the application of HP was limited by the relative bio-incompatibility of the sorbent material (uncoated charcoal based cartridges) and the significant side effects derived from its contact with blood. HP sessions were often accompanied by chills, fever, cutaneous rush, thrombocytopenia, leukopenia, and aluminum leaching. Direct contact of blood with charcoal in the absence of a biocompatible coating, however, is not advised. On the contrary, a coating may markedly reduce the adsorptive capacity of the carbon due to the size exclusion effect of the coating layer.

More recently, synthetic polymers with remarkable capacity of adsorption have been made available for clinical HP. The pores on the surface of the granules have been enlarged such that size exclusion has become a minor issue. Due to these recent advances, sorbent units are today available for direct HP and have been demonstrated to be quite efficient in removing poisons, bilirubin, cytokines etc1 with excellent biocompatibility & safety.

For many years, the use of sorbents was mostly proposed for chronic hemodialysis patients to remove molecules that were not easily removed by hemodialysis.

Sorbents were also indicated in case of drug intoxication and poisoning where toxin removal had to be obtained rapidly and efficiently. More recently, emerging clinical evidences provide a rationale for the use of sorbents in critical illness, sepsis, acute kidney injury, acute liver failure, acute on chronic liver failure due to the proposed humoral pathogenesis of these disorders.

 

Hemoperfusion Cartridges of Jafron marketed in India by Delvin Specialities:

Delvin Specialities, a flagship division of Delvin Conglomerate joined hands with Jafron, world’s largest adsorption column manufacturer and markets hemoperfusion cartridges in India.

All our HA cartridges are designed & meet the following essential requirements and deliver adequate adsorbent-based therapy:

  • Effective, biocompatible, and safe sorbent material (Styrene Divinylbenzene polymer – resin based sorbents)
  • Sorbent cartridge with adequate design and structure
  • Allowing operational conditions for optimal utilization of the available surface of the sorbent.

We are the only company having a range of hemoperfusion cartridges like HA 130, HA 230, HA 330 and HA 330-II / BS-330 for ESRD, Poisoning, Sepsis and Liver Failure respectively.

Based on the target molecules to be removed in different conditions like ESRD, Poison, Sepsis & Liver Failure, molecular sieve size of the three dimensional network structures on the sorbent surface is specifically designed and also functionalized with chemical compounds to target specific molecules for adsorption.